Human inherited CCR2 deficiency underlies progressive polycystic lung disease Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc'h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Susanta Pahari, Larry S Schlesinger, Nico Marr, Dusan Bugonovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E Sepulveda, Lawrence M Nogee, Nathalie Aladjidi, Bruce C Trapnell, Jean-Laurent Casanova, Jacinta Bustamante Cell, January 2024 https://doi.org/10.1016/j.cell.2023.11.036

Actin dynamics regulation by TTC7A/PI4KIIIα limits DNA damage and cell death under confinement Tania Gajardo, Mathilde Bernard, Marie Lô, Elisa Turck, Claire Leveau, Marie-Thérèse El-Daher, Alexandre Deslys, Patricia Panikulam, Constantin Menche, Mathieu Kurowska, Gregoire Le Lay, Lucie Barbier, Despina Moshous, Bénédicte Neven, Henner F Farin, Alain Fischer, Gaël Ménasché, Geneviève de Saint Basile, Pablo Vargas*, Fernando E Sepulveda Journal of Allergy and Clinical Immunology, October 2023 https://doi.org/10.1016/j.jaci.2023.06.016

Calcium channel β3 subunit regulates ATP-dependent migration of dendritic cells Marcel S Woo, Friederike Ufer, Jana K Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J Sáez, Paula F Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A Friese Science Advances, September 2023 https://doi.org/10.1126/sciadv.adh1653

Rai14 is a novel interactor of Invariant chain that regulates macropinocytosis Natacha Lobos Patorniti, Khalisah Liyana Zulkefli, Martin E McAdam, Pablo Vargas, Oddmund Bakke, Cinzia Progida Frontiers in Immunology, July 2023 https://doi.org/10.3389/fimmu.2023.1182180

The Unfolded Protein Response Sensor IRE1 Regulates Activation of In Vitro Differentiated Type 1 Conventional DCs with Viral Stimuli Bernardita Medel, José Ignacio Bernales, Alonso Lira, Dominique Fernández, Takao Iwawaki, Pablo Vargas*, Fabiola Osorio International Journal of Molecular Sciences, June 2023 https://doi.org/10.3390/ijms241210205

DOCK11 deficiency in patients with X-linked actinopathy and autoimmunity Charlotte Boussard, Laure Delage, Tania Gajardo, Alexandre Kauskot, Maxime Batignes, Nicolas Goudin, Marie-Claude Stolzenberg, Camille Brunaud, Patricia Panikulam, Quentin Riller, Maryse Moya-Nilges, Jean Solarz, Christelle Repérant, Béatrice Durel, Jean-Claude Bordet, Olivier Pellé, Corinne Lebreton, Aude Magérus, Vithura Pirabakaran, Pablo Vargas, Sébastien Dupichaud, Marie Jeanpierre, Angélique Vinit, Mohammed Zarhrate, Cécile Masson, Nathalie Aladjidi, Peter D Arkwright, Brigitte Bader-Meunier, Sandrine Baron Joly, Joy Benadiba, Elise Bernard, Dominique Berrebi, Christine Bodemer, Martin Castelle, Fabienne Charbit-Henrion, Marwa Chbihi, Agathe Debray, Philippe Drabent, Sylvie Fraitag, Miguel Hié, Judith Landman-Parker, Ludovic Lhermitte, Despina Moshous, Pierre Rohrlich, Frank Ruemmele, Anne Welfringer-Morin, Maud Tusseau, Alexandre Belot, Nadine Cerf-Bensussan, Marie Roelens, Capucine Picard, Bénédicte Neven, Alain Fischer, Isabelle Callebaut, Mickaël Ménager, Fernando E Sepulveda, Frédéric Adam, Frédéric Rieux-Laucat Blood, June 2023 https://doi.org/10.1182/blood.2022018486

Atypical CXCL12 signaling enhances neutrophil migration by modulating nuclear deformability Bianca Calì, Mathieu Deygas, Fabio Munari, Elisabetta Marcuzzi, Antonino Cassará, Lara Toffali, Massimo Vetralla, Mathilde Bernard, Matthieu Piel, Onelia Gagliano, Marta Mastrogiovanni, Carlo Laudanna, Nicola Elvassore, Barbara Molon, Pablo Vargas*, Antonella Viola Science Signaling, November 2022 https://doi.org/10.1126/scisignal.abk2552

The tumor suppressor adenomatous polyposis coli regulates T lymphocyte migration Marta Mastrogiovanni, Pablo Vargas, Thierry Rose, Céline Cuche, Elric Esposito, Marie Juzans, Hélène Laude, Amandine Schneider, Mathilde Bernard, Sophie Goyard, Charlotte Renaudat, Marie-Noëlle Ungeheuer, Jérôme Delon, Andrés Alcover, Vincenzo Di Bartolo Science Advances, April 2022 https://doi.org/10.1126/sciadv.abl5942

Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity Miriam Groß, Carsten Speckmann, Annette May, Tania Gajardo-Carrasco, Katharina Wustrau, Sarah Lena Maier, Marcus Panning, Daniela Huzly, Abbas Agaimy, Yenan T Bryceson, Sharon Choo, C W Chow, Gregor Dückers, Anders Fasth, Sylvie Fraitag, Katja Gräwe, Sabine Haxelmans, Dirk Holzinger, Ole Hudowenz, Judith M Hübschen, Claudia Khurana, Korbinian Kienle, Roman Klifa, Klaus Korn, Heinz Kutzner, Tim Lämmermann, Svea Ledig, Dan Lipsker, Marie Meeths, Nora Naumann-Bartsch, Jelena Rascon, Anne Schänzer, Maximilian Seidl, Bianca Tesi, Christelle Vauloup-Fellous, Beate Vollmer-Kary, Klaus Warnatz, Claudia Wehr, Bénédicte Neven, Pablo Vargas, Fernando E Sepulveda, Kai Lehmberg, Annette Schmitt-Graeff, Stephan Ehl Journal of Allergy and Clinical Immunology, January 2022 https://doi.org/10.1016/j.jaci.2021.05.007

Pinching the cortex of live cells reveals thickness instabilities caused by myosin II motors Valentin Laplaud, Nicolas Levernier, Judith Pineau, Mabel San Roman, Lucie Barbier, Pablo J. Sáez, Ana-Maria Lennon-Duménil, Pablo Vargas, Karsten Kruse, Olivia du Roure, Matthieu Piel, Julien Heuvingh Science Advances, July 2021 https://doi.org/10.1126/sciadv.abe3640

HIF2α is a direct regulator of neutrophil motility Sundary Sormendi, Mathieu Deygas, Anupam Sinha, Mathilde Bernard, Anja Krüger, Ioannis Kourtzelis, Gregoire Le Lay, Pablo J. Sáez, Michael Gerlach, Kristin Franke, Ana Meneses, Martin Kräter, Alessandra Palladini, Jochen Guck, Ünal Coskun, Triantafyllos Chavakis, Pablo Vargas*, Ben Wielockx Blood, June 2021 https://doi.org/10.1182/blood.2020007505

Sliding walls: a new paradigm for fluidic actuation and protocol implementation in microfluidics Bastien Venzac, Yang Liu, Ivan Ferrante, Pablo Vargas, Ayako Yamada, Rémi Courson, Marine Verhulsel, Laurent Malaquin, Jean-Louis Viovy, Stéphanie Descroix Microsystems & Nanoengineering, April 2020 https://doi.org/10.1038/s41378-019-0125-7

A statistical inference approach to reconstruct intercellular interactions in cell migration experiments Elena Agliari, Pablo J. Sáez, Adriano Barra, Matthieu Piel, Pablo Vargas, Michele Castellana Science Advances, March 2020 https://doi.org/10.1126/sciadv.aay2103

Predicting Confined 1D Cell Migration from Parameters Calibrated to a 2D Motor-Clutch Model Louis S. Prahl, Maria R. Stanslaski, Pablo Vargas, Matthieu Piel, David J. Odde Biophysical Journal, February 2020 https://doi.org/10.1016/j.bpj.2020.01.048

Deterministic actin waves as generators of cell polarization cues Luiza Stankevicins, Nicolas Ecker, Emmanuel Terriac, Paolo Maiuri, Rouven Schoppmeyer, Pablo Vargas, Ana-Maria Lennon-Duménil, Matthieu Piel, Bin Qu, Markus Hoth, Karsten Kruse, and Franziska Lautenschläger Proceedings of the National Academy of Sciences, December 2019 https://doi.org/10.1073/pnas.1907845117

Profilin and formin constitute a pacemaker system for robust actin filament growth Johanna Funk, Felipe Merino, Larisa Venkova, Lina Heydenreich, Jan Kierfeld, Pablo Vargas, Stefan Raunser, Matthieu Piel, Peter Bieling eLife, October 2019 https://doi.org/10.7554/eLife.50963

Myosin II Activity Is Selectively Needed for Migration in Highly Confined Microenvironments in Mature Dendritic Cells Lucie Barbier, Pablo J. Sáez, Rafaele Attia, Ana-Maria Lennon-Duménil, Ido Lavi, Matthieu Piel, Pablo Vargas* Frontiers in Immunology, April 2019 https://doi.org/10.3389/fimmu.2019.00747

Reconstitution of cell migration at a glance Juan Manuel Garcia-Arcos, Renaud Chabrier, Mathieu Deygas, Guilherme Nader, Lucie Barbier, Pablo J. Sáez, Aastha Mathur, Pablo Vargas, Matthieu Piel Journal of Cell Science, February 2019 https://doi.org/10.1242/jcs.225565

Innate Immune Signals Induce Anterograde Endosome Transport Promoting MHC Class I Cross-Presentation Mirjana Weimershaus, François-Xavier Mauvais, Loredana Saveanu, Cézaire Adiko, Joël Babdor, Anastasia Abramova, Sebastian Montealegre, Myriam Lawand, Irini Evnouchidou, Katharina Julia Huber, Alexandra Chadt, Markus Zwick, Pablo Vargas, Michael Dussiot, Ana Maria Lennon-Dumenil, Thomas Brocker, Hadi Al-Hasani, Peter van Endert Cell Reports, September 2018 https://doi.org/10.1016/j.celrep.2018.08.041

Role of calcium permeable channels in dendritic cell migration Pablo J. Sáez, Juan C. Sáez, Ana-María Lennon-Duménil, Pablo Vargas* Current Opinion in Immunology, April 2018 https://doi.org/10.1016/j.coi.2018.04.005

Leukocyte Migration and Deformation in Collagen Gels and Microfabricated Constrictions Pablo J. Sáez, Lucie Barbier, Rafaele Attia, Hawa-Racine Thiam, Matthieu Piel, Pablo Vargas* Methods in Molecular Biology, March 2018 https://doi.org/10.1007/978-1-4939-7701-7_26

Diversification of human plasmacytoid predendritic cells in response to a single stimulus Solana G. Alculumbre, Violaine Saint-André, Jeremy Di Domizio, Pablo Vargas, Philemon Sirven, Pierre Bost, Mathieu Maurin, Paolo Maiuri, Maxime Wery, Mabel San Roman, Léa Savey, Maxime Touzot, Benjamin Terrier, David Saadoun, Curdin Conrad, Michel Gilliet, Antonin Morillon, Vassili Soumelis Nature Immunology, January 2018 https://doi.org/10.1038/s41590-017-0012-z

Caveolin-1 Expression Increases upon Maturation in Dendritic Cells and Promotes Their Migration to Lymph Nodes Thereby Favoring the Induction of CD8+ T Cell Responses Cesar Oyarce, Sebastián Cruz-Gomez, Felipe Galvez-Cancino, Pablo Vargas, Hélène D. Moreau, Natalia Diaz-Valdivia, Jorge Diaz, Flavio Andres Salazar-Onfray, Rodrigo Pacheco, Ana Maria Lennon-Dumenil, Andrew F. G. Quest, Alvaro Lladser Frontiers in Immunology, December 2017 https://doi.org/10.3389/fimmu.2017.01794

ATP promotes the fast migration of dendritic cells through the activity of pannexin 1 channels and P2X7 receptors Pablo J. Sáez, Pablo Vargas, Kenji F. Shoji, Paloma A. Harcha, Ana-Maria Lennon-Duménil, Juan C. Sáez Science Signaling, November 2017 https://doi.org/10.1126/scisignal.aah7107

A tuneable microfluidic system for long duration chemotaxis experiments in a 3D collagen matrix Koceila Aizel, Andrew G. Clark, Anthony Simon, Sara Geraldo, Anette Funfak, Pablo Vargas, Jérôme Bibette, Danijela Matic Vignjevic, Nicolas Bremond Lab on a chip, November 2017 https://doi.org/10.1039/c7lc00649g

UNC93B1 interacts with the calcium sensor STIM1 for efficient antigen cross-presentation in dendritic cells Sophia Maschalidi, Paula Nunes-Hasler, Clarissa R Nascimento, Ignacio Sallent, Valérie Lannoy, Meriem Garfa-Traore, Nicolas Cagnard, Fernando E. Sepulveda, Pablo Vargas, Ana-Maria Lennon-Duménil, Peter van Endert, Thierry Capiod, Nicolas Demaurex, Guillaume Darrasse-Jèze, Bénédicte Manoury Nature Communications, November 2017 https://doi.org/10.1038/s41467-017-01601-5

Lysosome signaling controls the migration of dendritic cells Marine Bretou, Pablo J. Sáez, Doriane Sanséau, Mathieu Maurin, Danielle Lankar, Melanie Chabaud, Carmine Spampanato, Odile Malbec, Lucie Barbier, Shmuel Muallem, Paolo Maiuri, Andrea Ballabio, Julie Helft, Matthieu Piel, Pablo Vargas*, Ana-Maria Lennon-Duménil Science Immunology, October 2017 https://doi.org/10.1126/sciimmunol.aak9573

Mechanisms for fast cell migration in complex environments Pablo Vargas*, Lucie Barbier, Pablo J. Sáez, Matthieu Piel Current Opinion in Cell Biology, October 2017 https://doi.org/10.1016/j.ceb.2017.04.007

Arc/Arg3.1 governs inflammatory dendritic cell migration from the skin and thereby controls T cell activation Friederike Ufer, Pablo Vargas, Jan Broder Engler, Joseph Tintelnot, Benjamin Schattling, Hana Winkler, Simone Bauer, Nina Kursawe, Anne Willing, Oliver Keminer, Ora Ohana, Gabriela Salinas-Riester, Ole Pless, Dietmar Kuhl, Manuel A. Friese Science Immunology, September 2016 https://doi.org/10.1126/sciimmunol.aaf8665

Study of dendritic cell migration using micro-fabrication Pablo Vargas*, Mélanie Chabaud, Hawa-Racine Thiam, Danielle Lankar, Matthieu Piel, Ana-Maria Lennon-Duménil Journal of Immunological Methods, May 2016 https://doi.org/10.1016/j.jim.2015.12.005

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death Matthew Raab, Matteo Gentili, Henry De Belly, Hawa-Racine Thiam, Pablo Vargas, Ana Joaquina Jimenez, Franziska Lautenschlaeger, Raphaël Voituriez, Ana-Maria Lennon-Duménil, Nicolas Manel, Matthieu Piel Science, March 2016 https://doi.org/10.1126/science.aad7611

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments Hawa-Racine Thiam, Pablo Vargas, Nicolas Carpi, Carolina Lage Crespo, Matthew Raab, Emmanuel Terriac, Megan C. King, Jordan Jacobelli, Arthur S. Alberts, Theresia Stradal, Ana-Maria Lennon-Dumenil, Matthieu Piel Nature Communications, March 2016 https://doi.org/10.1038/ncomms10997

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells Pablo Vargas*, Paolo Maiuri, Marine Bretou, Pablo J. Sáez, Paolo Pierobon, Mathieu Maurin, Mélanie Chabaud, Danielle Lankar, Dorian Obino, Emmanuel Terriac, Matthew Raab, Hawa-Racine Thiam, Thomas Brocker, Susan M. Kitchen-Goosen, Arthur S. Alberts, Praveen Sunareni, Sheng Xia, Rong Li, Raphael Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil Nature Cell Biology, January 2016 https://doi.org/10.1038/ncb3284

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens Andrés Alloatti, Fiorella Kotsias, Anne-Marie Pauwels, Jean-Marie Carpier, Mabel Jouve, Evy Timmerman, Luigia Pace, Pablo Vargas, Mathieu Maurin, Ulf Gehrmann, Leonel Joannas, Omar I. Vivar, Ana-Maria Lennon-Duménil, Ariel Savina, Kris Gevaert, Rudi Beyaert, Eik Hoffmann, Sebastian Amigorena Immunity, December 2015 https://doi.org/10.1016/j.immuni.2015.11.006

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells Mélanie Chabaud, Mélina L. Heuzé, Marine Bretou, Pablo Vargas, Paolo Maiuri, Paola Solanes, Mathieu Maurin, Emmanuel Terriac, Maël Le Berre, Danielle Lankar, Tristan Piolot, Robert S. Adelstein, Yingfan Zhang, Michael Sixt, Jordan Jacobelli, Olivier Bénichou, Raphaël Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil Nature Communications, June 2015 https://doi.org/10.1038/ncomms8526

Space exploration by dendritic cells requires maintenance of myosin II activity by IP3 receptor 1 Paola Solanes, Mélina L. Heuzé, Mathieu Maurin, Marine Bretou, Franziska Lautenschlaeger, Paolo Maiuri, Emmanuel Terriac, Maria-Isabel Thoulouze, Pierre Launay, Matthieu Piel, Pablo Vargas*, Ana-Maria Lennon-Duménil The EMBO Journal, March 2015 https://doi.org/10.15252/embj.201489056

Study of cell migration in microfabricated channels Pablo Vargas, Emmanuel Terriac, Ana-Maria Lennon-Duménil, Matthieu Piel JoVE, February 2014 https://doi.org/10.3791/51099

Migration of dendritic cells: physical principles, molecular mechanisms, and functional implications Pablo Vargas, Mélina L. Heuzé, Mélanie Chabaud, Maël Le Berre, Yan-Jun Liu, Olivier Collin, Paola Solanes, Raphaël Voituriez, Matthieu Piel, Ana-Maria Lennon-Duménil Immunological Reviews, November 2013 https://doi.org/10.1111/imr.12108

Epithelial control of the human pDC response to extracellular bacteria Paula Michea, Pablo Vargas, Marie-Hélène Donnadieu, Mario Rosemblatt, María Rosa Bono, Guillaume Duménil, Vassili Soumelis European Journal of Immunology, May 2013 https://doi.org/10.1002/eji.201242990

A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells Laurence Bougnères, Julie Helft, Sangeeta Tiwari, Pablo Vargas, Benny Hung-Junn Chang, Lawrence Chan, Laura Campisi, Gregoire Lauvau, Stephanie Hugues, Pradeep Kumar, Alice O Kamphorst, Ana-Maria Lennon Duménil, Michel Nussenzweig, John D. MacMicking, Sebastian Amigorena, Pierre Guermonprez Immunity, August 2009 https://doi.org/10.1016/j.immuni.2009.06.022

Measuring pH, ROS Production, Maturation, and Degradation in Dendritic Cell Phagosomes Using Cytofluorometry-Based Assays Ariel Savina, Pablo Vargas, Pierre Guermonprez, Ana-Maria Lennon, Sebastian Amigorena Methods in Molecular Biology, January 2009 https://doi.org/10.1007/978-1-60761-421-0_25

Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain Pablo Vargas, Gabrielle Faure-André, Maria-Isabel Yuseff, Mélina Heuzé, Jheimmy Diaz, Danielle Lankar, Veronica Steri, Jeremy Manry, Stéphanie Hugues, Fulvia Vascotto, Jérôme Boulanger, Graça Raposo, Maria-Rosa Bono, Mario Rosemblatt, Matthieu Piel, Ana-Maria Lennon-Duménil Science, December 2008 https://doi.org/10.1126/science.1159894

The actin-based motor protein myosin II regulates MHC class II trafficking and BCR-driven antigen presentation Fulvia Vascotto, Danielle Lankar, Gabrielle Faure-André, Pablo Vargas, Jheimmy Diaz, Delphine Le Roux, Maria-Isabel Yuseff, Jean-Baptiste Sibarita, Marianne Boes, Graça Raposo, Evelyne Mougneau, Nicolas Glaichenhaus, Christian Bonnerot, Bénédicte Manoury, Ana-Maria Lennon-Duménil Journal of Cell Biology, March 2007 https://doi.org/10.1083/jcb.200611147

Antigen presentation by B lymphocytes: how receptor signaling directs membrane trafficking Fulvia Vascotto, Delphine Le Roux, Danielle Lankar, Gabrielle Faure-André, Pablo Vargas, Pierre Guermonprez, Ana-Maria Lennon-Duménil Current Opinion in Immunology, November 2006 https://doi.org/10.1016/j.coi.2006.11.011

NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells Ariel Savina, Carolina Jancic, Stephanie Hugues, Pierre Guermonprez, Pablo Vargas, Ivan Cruz Moura, Ana-Maria Lennon-Duménil, Miguel C. Seabra, Graça Raposo, Sebastian Amigorena Cell, July 2006 https://doi.org/10.1016/j.cell.2006.05.035

Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens Pablo Vargas, Claudio Cortés, Leonardo Vargas, Mario Rosemblatt, María Rosa Bono Immunobiology, January 2006 https://doi.org/10.1016/j.imbio.2005.09.002